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[Product Highlight] Sulfonyl Azide Useful for Introduction of Azido and Diazo Groups
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[20240129]
"Sulfonyl Azide Useful for Introduction of Azido and Diazo Groups"
2,4,6-Triisopropylbenzenesulfonyl azide (1) can be used as an electrophilic azidation agent or a diazotizing agent.1,2) When 1 reacts with a suitable base on a substrate containing a carbonyl group, an azido or diazo group can be introduced at the α-position. Recently, decarboxylative azidation reactions using visible light redox catalysts have also been reported.3) For example, using proline derivatives as substrates yield 2-azidopyrrolidine derivatives.
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References
- 1) A General Method for Making Peptide Therapeutics Resistant to Serine Protease Degradation: Application to Dipeptidyl Peptidase IV Substrates
- 2) Symmetry in retrosynthetic analysis:(±)-pentalenolactone e methyl ester
- 3) Photoinduced decarboxylative azidation of cyclic amino acids
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